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Lactoferrin in human ocular tissues

T E Gillette, M R Allansmith

    American Journal of Ophthalmology
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    The primary source of lactoferrin in human tears is the acinar epithelium of the main and accessory lacrimal glands, not conjunctival tissue. This finding clarifies the origin of this important tear protein.

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    Area of Science:

    • Ophthalmology
    • Immunohistochemistry
    • Molecular Biology

    Background:

    • Lactoferrin is a key protein found in human tears, contributing to their antimicrobial and anti-inflammatory properties.
    • The precise origin of lactoferrin within the ocular surface tissues has been a subject of investigation.

    Purpose of the Study:

    • To determine the primary source of lactoferrin in normal human tears.
    • To localize lactoferrin within lacrimal and conjunctival tissues using immunohistology.

    Main Methods:

    • Immunohistologic examination of lacrimal gland tissue (main and accessory) and conjunctival biopsy specimens.
    • Analysis of samples from autopsy cases and patients.

    Main Results:

    • Lactoferrin was identified in the acinar epithelial cells of both main and accessory lacrimal glands.

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  • Lactoferrin was not detected in conjunctival tissue, except within neutrophils.
  • The acinar epithelium of lacrimal glands was confirmed as the primary site of lactoferrin production.

    • Conclusions:

    • The main and accessory lacrimal glands are the principal source of lactoferrin in human tears.
    • Conjunctival tissue does not significantly contribute to tear lactoferrin levels.
    • This study elucidates the origin of lactoferrin, crucial for understanding tear film function.