Role of renal prostaglandins in circulatory homeostasis

The evidence is reviewed that prostaglandins of renal origin through (i) their local actions on renal blood vessels, and (ii) complex interactions with the nervous adrenergic and the endocrine vasoactive renin-angiotensin-aldosterone and kallikrein-kinin systems, may participate in the regulation of excretory functions of the kidney and thereby contribute to circulatory homeostatic mechanisms.