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Cromones in atopic dermatitis

J Søndergaard, V Kassis, L Knudsen

    Archives of Dermatological Research
    |January 1, 1980
    PubMed
    Summary
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    New cromone compounds show potential for treating atopic dermatitis. Intradermal injection of FPL 52758 reduced allergic reactions, but topical application was ineffective. Further research is needed for effective topical treatments.

    Area of Science:

    • Pharmacology
    • Dermatology
    • Allergology

    Background:

    • Disodium cromoglycate is a standard anti-allergic medication.
    • Newer cromone derivatives are being investigated for improved absorption and broader anti-allergic activity.
    • Atopic dermatitis is a chronic inflammatory skin condition characterized by allergic reactions.

    Purpose of the Study:

    • To evaluate the efficacy of new cromone compounds, specifically FPL 52758, FPL 52757, and FPL 57787, in managing allergic reactions and atopic dermatitis.
    • To compare the anti-allergic effects of different administration routes (intradermal vs. topical) for FPL 52758.
    • To assess the safety and efficacy of topical FPL 57787 in patients with atopic dermatitis.

    Main Methods:

    • An intradermal injection of 10 micrograms of FPL 52758 was administered to 11 patients with atopic dermatitis prior to antigen challenge.

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  • Topical application of 1.5 mg of FPL 52758 under occlusion for 24 hours was tested in the same patients.
  • A double-blind, within-patient study involved nine patients with mild to moderate atopic dermatitis treated with 5% FPL 57787 ointment or placebo.

    • Main Results:

    • Intradermal FPL 52758 significantly reduced antigen-induced weal and flare reactions and associated symptoms like itch and pain.
    • Topical FPL 52758 did not reduce the weal and flare reaction.
    • Topical FPL 57787 showed no significant improvement in atopic dermatitis symptoms after 4 weeks of treatment compared to placebo.

    Conclusions:

    • Intradermal administration of FPL 52758 demonstrates potential for acute management of allergic skin reactions.
    • Topical application of FPL 52758 and FPL 57787 appears ineffective for treating atopic dermatitis.
    • Further investigation into alternative delivery methods or different cromone compounds is warranted for effective topical atopic dermatitis therapy.