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[Experimental Echinococcus multilocularis infections of the maternal mouse and their significance for the offspring]
Experimental infection of mother mice by intraperitoneal injection of Echinococcus multilocularis cyst material does not result in the transfer of protective immunity to the offspring. In the contrary, if infected via the same route, filial mice show a lower antibody titer, when examined 36, 78 and 120 days p.i. and a higher worm burden (average: 1455 mg) in comparison with control mice born of non-infected mothers (average parasite weight: 844 mg). The question is discussed, whether these observations are due to the suppressive action of transferred antibodies or whether the offspring become immunologically tolerant by the transfer of parasite antigen.
Experimental infection of mother mice by intraperitoneal injection of Echinococcus multilocularis cyst material does not result in the transfer of protective immunity to the offspring. In the contrary, if infected via the same route, filial mice show a lower antibody titer, when examined 36, 78 and 120 days p.i. and a higher worm burden (average: 1455 mg) in comparison with control mice born of non-infected mothers (average parasite weight: 844 mg). The question is discussed, whether these observations are due to the suppressive action of transferred antibodies or whether the offspring become immunologically tolerant by the transfer of parasite antigen.