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[The function of microphages in chronic recurrent pyodermias]
Zeitschrift Fur Hautkrankheiten
|June 1, 1980
Summary
Patients with chronic skin infections show impaired polymorphonuclear leukocyte (PMNL) function, including reduced chemotaxis and intracellular killing. These findings highlight PMNLs' critical role in the body's primary defense against infections.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Chronic recurrent pyogenic skin infections can indicate underlying immune dysfunction.
- Polymorphonuclear leukocytes (PMNLs) are crucial immune cells involved in pathogen clearance.
Purpose of the Study:
- To assess polymorphonuclear leukocyte (PMNL) function in patients with chronic recurrent pyogenic skin infections.
- To compare PMNL function between patients and healthy controls.
Main Methods:
- In vitro functional tests were conducted on PMNLs from 20 patients and 20 healthy controls.
- Assessed parameters included chemotaxis, intracellular killing of microorganisms, and NADH-dependent oxidase activity.
Main Results:
- Patients exhibited significantly impaired PMNL chemotaxis and intracellular killing compared to controls.
- Phagocytosis of Candida albicans cells was also notably reduced in patients.
- Microphage motility remained normal, distinguishing PMNL-specific deficits.
Conclusions:
- The study demonstrates significant functional deficits in polymorphonuclear leukocytes (PMNLs) in patients with chronic pyogenic skin infections.
- These PMNL impairments underscore their vital importance in the primary defense mechanisms of the body.