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Related Experiment Videos

Herpes gestationis associated with the C3 nephritic factor

R Grimwood, C M Arroyave, W L Weston

    Archives of Dermatology
    |September 1, 1980
    PubMed
    Summary

    Herpes gestationis, a pregnancy-related blistering disease, involves immune deposits at the skin's basement membrane. This study identified a novel complement factor in a patient with this condition.

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    Area of Science:

    • Immunodermatology
    • Complement System Immunology
    • Autoimmune Blistering Diseases

    Background:

    • Herpes gestationis (HG) is a rare autoimmune blistering disease during pregnancy.
    • Immunopathology involves C3 and IgG deposits at the dermoepidermal basement membrane zone (BMZ).
    • A circulating IgG factor activating the classic complement pathway has been previously identified in HG.