Transient hypoglycemia following 25-hydroxycholecalciferol administraton to mice

A transient hypoglycemia was found 4 hrs after injection of 25-hydroxycholecalciferol (25-HCC) in mice. This was not associated with any significant alteration in the serum insulin concentration, suggesting that the hypoglycemic response is due to extrapancreatic factors. Pretreatment with 25-HCC did not affect the development of alloxan diabetes.