Induction of implantation by androgens in mice with delayed implantation

Testosterone and 5 alpha-dihydrotestosterone (5 alpha-DHT) were able to mimic the action of oestradiol-17 beta in initiating implantation in ovariectomized, progesterone-treated mice. Cyproterone acetate and CI-628 were capable of inhibiting the testosterone-induced response, but CI-628 citrate prevented only the 5 alpha-DHT-mediated implantation reaction. It is suggested that testosterone acts through testosterone and oestrogen receptors while 5 alpha-DHT acts only through oestrogen receptors.