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Related Experiment Videos

[Polyunsaturated fatty acids and aging. Lipofuscins : structure, origin and development]

G Durand, F Desnoyers

    Annales De La Nutrition Et De L'Alimentation
    |January 1, 1980
    PubMed
    Summary

    Cellular lipofuscin, an age pigment, accumulates with physiological aging. Its concentration, influenced by intrinsic and environmental factors, is a key indicator of aging across tissues.

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    A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex.

    Nanoscale·2017

    Area of Science:

    • Cellular Biology
    • Biochemistry
    • Aging Research

    Context:

    • Pigmented bodies observed in nerve cells correlate with individual age.
    • These pigments are present in most vertebrate and invertebrate tissues, and cultured cells.
    • Detailed study of these cellular components has intensified in the last 25 years.

    Purpose:

    • To describe the nature, origin, development, and physiological role of cellular pigments.
    • To elucidate the common biochemical mechanism underlying the formation of these pigments.
    • To establish the relationship between pigment concentration and physiological age.

    Summary:

    • Cellular pigments, commonly termed lipofuscins, form via peroxidation of polyunsaturated fatty acids, reaction with proteins, and combination with peroxidized lipids.
    • Morphology, composition, and physicochemical properties suggest a unified biochemical origin for these diverse pigments.
    • Lipofuscin concentration is confirmed to correlate with physiological age, varying by tissue and influenced by environmental factors.

    Impact:

    • Advances understanding of the aging process at a cellular level.
    • Provides a biochemical basis for age-related pigment formation.
    • Highlights the influence of lifestyle and environmental factors on cellular aging markers.

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