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Obesity and diabetes

J Vague, P Vague, M Tramoni

    Acta Diabetologica Latina
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Android obesity, not total fat mass, drives diabetes progression. This upper-body fat distribution is linked to factors causing obesity, diabetes, and atherosclerosis, termed diabetogenic and atherogenic obesity.

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    Area of Science:

    • Endocrinology
    • Metabolic Diseases
    • Cardiovascular Health

    Background:

    • Obesity is a complex metabolic condition with significant health implications.
    • The relationship between body fat distribution and the development of associated comorbidities like diabetes and atherosclerosis requires further clarification.

    Purpose of the Study:

    • To investigate the role of fat mass versus fat distribution in the progression of obesity towards diabetes.
    • To identify specific obesity phenotypes associated with increased risk for diabetes and atherosclerosis.

    Main Methods:

    • Analysis of body fat distribution and its correlation with metabolic markers.
    • Assessment of insulin and cortisol secretion in relation to body fat.
    • Longitudinal observation of obesity progression through distinct stages.

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    Main Results:

    • Total body fat mass has minimal impact on obesity progression to diabetes.
    • Android obesity (upper body fat predominance) is a key indicator of factors leading to diabetes and atherosclerosis.
    • Insulin and cortisol secretion correlate with upper body fat distribution, not overall fat mass.
    • A 5-stage progression from obesity to insulin-dependent diabetes is proposed for individuals with diabetogenic obesity.

    Conclusions:

    • Android obesity should be classified as diabetogenic and atherogenic obesity.
    • Body fat distribution, particularly androidal, is critical in the pathogenesis of obesity-related metabolic and cardiovascular diseases.
    • The precise mechanisms driving or preventing the progression of diabetogenic obesity remain to be elucidated.