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Recurrent keratoconus after keratoplasty

M B Abelson, H B Collin, T E Gillette

    American Journal of Ophthalmology
    |November 1, 1980
    PubMed
    Summary
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    Keratoconus, a corneal disease, can recur in a corneal graft years after transplantation. This case report highlights keratoconus developing in a 16-year-old corneal graft, suggesting it as a late complication.

    Area of Science:

    • Ophthalmology
    • Corneal Transplantation
    • Histopathology

    Background:

    • Keratoconus is a progressive thinning of the cornea.
    • Penetrating keratoplasty (corneal transplant) is a common treatment for advanced keratoconus.
    • Graft failure or disease recurrence can occur after corneal transplantation.

    Observation:

    • A 35-year-old woman presented with recurrent keratoconus in a corneal graft received 16 years prior.
    • A repeat penetrating keratoplasty was performed.
    • The excised corneal graft tissue was analyzed using light and electron microscopy.

    Findings:

    • Microscopic examination confirmed the presence of keratoconus in the excised corneal graft.
    • Histopathological findings correlated with the clinical diagnosis of keratoconus.

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  • This indicates that keratoconus can develop within a previously transplanted cornea.

    • Implications:

    • Keratoconus developing in a corneal graft is a potential late complication of penetrating keratoplasty.
    • This finding expands the understanding of long-term outcomes after corneal transplantation for keratoconus.
    • Ophthalmologists should consider graft-related keratoconus in the differential diagnosis of visual decline in transplant recipients.