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Related Experiment Videos

Haemodynamic changes following buprenorphine and morphine

D H Scott, G R Arthur, D B Scott

    Anaesthesia
    |October 1, 1980
    PubMed
    Summary

    This study found that intravenous buprenorphine and morphine had similar hemodynamic effects in women post-abdominal surgery. Both drugs caused minor reductions in blood pressure and cardiac output without significantly altering myocardial contractility.

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    Area of Science:

    • Anesthesiology
    • Cardiovascular Pharmacology

    Background:

    • Post-abdominal surgery pain management often involves opioids.
    • Understanding the hemodynamic effects of different analgesics is crucial for patient safety.

    Purpose of the Study:

    • To compare the hemodynamic effects of intravenous buprenorphine and morphine in women after lower abdominal surgery.
    • To assess changes in arterial blood pressure and cardiac output following administration of these analgesics.

    Main Methods:

    • A single-blind, non-cross-over trial involving 25 women.
    • Hemodynamic parameters including arterial blood pressure (sphygmomanometry) and cardiac output (thoracic impedance cardiography) were measured.
    • Myocardial contractility was assessed using systolic time indices.

    Main Results:

    • Both buprenorphine (0.3 mg) and morphine (7.5 mg) significantly reduced arterial blood pressure (p < 0.05), with mean decreases less than 8 mmHg.
    • Cardiac output showed a mean reduction of less than 5%, with maximum individual decreases of 21% for buprenorphine and 30% for morphine.
    • No consistent differences in hemodynamic effects were observed between buprenorphine and morphine.

    Conclusions:

    • Intravenous buprenorphine and morphine exhibit comparable hemodynamic profiles in the immediate postoperative period following lower abdominal surgery.
    • Neither drug demonstrated significant adverse effects on myocardial contractility.
    • The choice between buprenorphine and morphine may not be dictated by substantial differences in acute hemodynamic impact.

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