Fc receptor mediated immune regulation and gene expression

Exogenous Fc receptors (FcR) have been demonstrated to either augment or inhibit endogenous FcR mediated immunity, immune regulation and gene expression. Other immune regulatory or modulator molecules, such as the H2 histocompatibility antigens, interferon, transfer factor and leukocyte chalones might involve association with or alter the synthesis or status of FcR, thus effecting regulation of immunity and/or gene expression. FcR provide a unique opportunity for eliciting the mechanisms and perhaps altering the immunity and/or gene expression which influence immune regulation, cellular differentiation, viral replication and malignant transformation.