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Mutagenic activity of N-chloropiperidine
Journal of Environmental Pathology and Toxicology
|September 1, 1980
Summary
N-chloropiperidine (NCP) is more toxic and mutagenic than piperidine (PD). NCP
Area of Science:
- Toxicology
- Mutagenesis
- Chemical Safety
Background:
- Piperidine (PD) and N-chloropiperidine (NCP) are nitrogen-containing heterocyclic compounds.
- Assessing the toxicological and mutagenic profiles of chemical compounds is crucial for risk assessment.
Purpose of the Study:
- To evaluate and compare the toxicity and mutagenicity of N-chloropiperidine (NCP) and piperidine (PD).
- To investigate the stability-dependent toxicity of NCP in aqueous solutions.
Main Methods:
- Toxicity was assessed in C57Bl/J6 mice via single intraperitoneal administration.
- Mutagenicity was evaluated using Salmonella tester strains (TA100, TA1535) via direct incorporation and modified host-mediated assays.
- Analysis included urine, peritoneal fluid, and fecal material from treated mice.
Main Results:
- The toxicity of aqueous piperidine (PD) decreased over time, while N-chloropiperidine (NCP) toxicity increased with storage.
- NCP induced approximately 2.4 times more revertants than PD in Salmonella strains TA100 and TA1535.
- Peritoneal fluid from NCP-treated mice showed higher mutagenic activity, followed by fecal material, urine, and urinary preparations.
Conclusions:
- N-chloropiperidine (NCP) exhibits greater mutagenic potential than piperidine (PD).
- The stability of NCP in aqueous solution influences its toxicological profile.
- Further investigation into the metabolic pathways and genotoxicity of NCP is warranted.