Shipping fever pasteurellosis and salmonellosis prophylaxis

Area of Science:

• Veterinary immunology
• Bacteriology
• Animal health

Background:

• Shipping fever (pasteurellosis) and salmonellosis are significant diseases in ranch calves.
• Conventional bacterins have limitations in efficacy and speed of protection.
• The need for improved prophylactic agents against these economically important diseases.

Purpose of the Study:

• To evaluate the efficacy of a novel water-in-oil emulsion adjuvanted combination shipping fever bacterin.
• To compare its immunogenicity and protective capacity against aluminum hydroxide adjuvanted bacterins and conventional types.
• To assess its prophylactic potential against Pasteurella multocida, Pasteurella hemolytica, and Salmonella typhimurium infections.

Main Methods:

• Field trials involving ranch calves vaccinated with the water-in-oil emulsion bacterin.
• Comparison of antibody response with an aluminum hydroxide adjuvanted bacterin.
• Critical 30-hour post-vaccination challenge mouse tests to assess protection against specific pathogens.

Main Results:

• The water-in-oil emulsion bacterin demonstrated effectiveness in field use for preventing shipping fever pasteurellosis and salmonellosis.
• It elicited a greater antibody response in ranch calves compared to an aluminum hydroxide adjuvanted bacterin.
• In mouse challenge tests, it proved superior to conventional bacterins, inducing rapid and significant protection.

Conclusions:

• Water-in-oil emulsion adjuvanted combination shipping fever bacterin is a highly effective prophylactic agent.
• This formulation offers enhanced immunogenicity and rapid protective capabilities against key bovine pathogens.
• It represents a significant advancement over existing bacterin technologies for managing shipping fever and salmonellosis.