De novo cutaneous neoplasm: biologic behavior in an immunosuppressed patient

The treatment of cutaneous squamous cell carcinoma in patients who are immunosuppressed should include early and adequate excision and extremely close follow-up. If the patients' tumor is aggressive, treatment should be aggressive even with discontinuation of the immunosuppression, which may lead to the death of the allograft. Sacrifice of the allograft in such an instance will lead to survival of the patient. In our patient, the continuous survival of the allograft with good renal function, in spite of the discontinuation of the immunosuppressive agents, can be interpreted only on the basis of graft adaptation.