Radionuclide biokinetics and internal dosimetry in nuclear medicine

In this review the present status of internal dosimetry for radiopharmaceuticals is summarized. Basic concepts of calculating the age-dependent mean tissue dose and the distribution of the local tissue dose are presented together with the fundamentals of biokinetics. Based on these dosimetric and biokinetic concepts, values of the absorbed dose for numerous radiopharmaceuticals are compiled. The accuracy of internal dose calculations is discussed quantitatively.