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Morphological commitment in Candida albicans

W L Chaffin, D E Wheeler

    Canadian Journal of Microbiology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Stationary phase Candida albicans cells can grow as yeast or hyphae. Commitment to hyphal growth at 37°C precedes yeast budding at 25°C, suggesting independent pathways for dimorphic transition.

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    Area of Science:

    • Mycology
    • Cell Biology
    • Microbiology

    Background:

    • Candida albicans is a dimorphic fungus that can exist as yeast or hyphae.
    • Stationary phase cells can reinitiate growth as either yeast or hyphae depending on environmental cues.

    Purpose of the Study:

    • To investigate the commitment points for yeast budding and hyphal germ tube formation in Candida albicans.
    • To determine the kinetics and independence of these two developmental pathways.

    Main Methods:

    • Stationary phase Candida albicans cells were resuspended in fresh medium at 25°C (yeast growth) and 37°C (hyphal growth).
    • Temperature shift experiments were performed to analyze the timing of commitment to each growth form.
    • Cell volume distribution was analyzed in relation to growth commitment.

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    Main Results:

    • Commitment to germ tube formation at 37°C precedes commitment to yeast bud formation at 25°C.
    • The commitment processes for hyphal and yeast growth appear independent.
    • The rate of commitment to germ tube formation followed first-order kinetics, suggesting a random process.
    • Cell volume correlated with commitment to yeast growth and bud emergence.

    Conclusions:

    • Candida albicans exhibits distinct and independent commitment points for yeast and hyphal development.
    • The timing and kinetics of commitment are influenced by temperature and cell physiology.
    • Understanding these pathways is crucial for controlling Candida albicans morphology and pathogenesis.