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Published on: April 20, 2011

A controlled trial with inactivated poliovaccine

T A Swartz, E Ben-Porath, Z Ben-Yshai

    Developments in Biological Standardization
    |January 1, 1981
    PubMed

    Insights

    Early vaccination with inactivated polio vaccine (IPV) in infants demonstrated high efficacy. Two doses of IPV achieved a 100% antibody response to poliovirus type 1, offering promising protection.

    Area of Science:

    • Pediatrics
    • Immunology
    • Vaccinology

    Background:

    • Poliovirus type 1 is highly prevalent in rural environments.
    • Early infant vaccination is crucial to prevent poliovirus exposure.
    • Inactivated polio vaccine (IPV) offers a potential strategy for early immunization.

    Purpose of the Study:

    • To evaluate the immunogenicity of an early inactivated polio vaccine (IPV) schedule in infants.
    • To compare the immune response to IPV with the traditional oral poliovirus vaccine (TOPV).
    • To assess the feasibility of early IPV administration in rural settings.

    Main Methods:

    • A field trial involving 115 infants primed with DPT-polio at 2 and 3.5 months.
    • Infants received a booster at 10 months with either DPT-polio (IPV) or DTP-TOPV.
    • A control group of 53 infants received TOPV at 2, 4, 6, and 12 months.

    Main Results:

    • One dose of IPV induced type 1 polio antibodies in 83% of infants.
    • Two doses of IPV resulted in a 100% antibody response.
    • A significant anamnestic response was observed after a booster dose.
    • IPV immunogenicity compared favorably with TOPV response.

    Conclusions:

    • Early IPV vaccination is effective in inducing robust antibody responses in infants.
    • IPV provides a viable alternative to TOPV for early poliovirus protection.
    • The findings support the implementation of IPV for early infant immunization programs.

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