Noncompliance with post-transplant immunosuppression

Two cases from an adolescent dialysis group are presented to illustrate the limitations of the generally used models of patient compliance and noncompliance with medical treatment. Understanding the noncompliance of these two young men required awareness of their psychological development and of the interpersonal matrix in which they lived. Their noncompliance was the result of a failure to master a transition from dependence to autonomy which probably could not have been predicted in advance, but which might have detected as it developed and might have been avoided through appropriate interventions with the patients and their families.