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Updated: Aug 7, 2026

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium
06:27

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

Published on: November 21, 2014

Evolution of modern concepts of hemostasis. A backward glance at the discoveries that made modern practice possible

C W McMillan

    The American Journal of Pediatric Hematology/Oncology
    |January 1, 1981
    PubMed

    Most of our current knowledge about the roles of blood vessels, platelets, and plasma factors in hemostasis has been gained in the last three decades. However, prior to this period a relatively limited but critical framework of ideas about hemostasis had slowly but steadily evolved, beginning in 1666 when Malpighi discovered fibrin in blood clots. By the turn of the 20th century aggregation of platelets at the site of blood vessel injury was recognized and four enduring coagulation factors emerged: fibrinogen, prothrombin, tissue extracts (thromboplastin), and calcium. Them progress exploded after World War II, leading us into a search for the molecular basis of hemostasis where we are today. Through it all, observations made at the bedside by astute clinicians have been a driving force in the advancement of basic knowledge.

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