Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclic platelet dysfunction in IgE-mediated allergy

J S Gallagher, I L Bernstein, C A Maccia

    The Journal of Allergy and Clinical Immunology
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The ability of low-magnitude mechanical signals to normalize bone turnover in adolescents hospitalized for anorexia nervosa.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016
    Same author

    The immune profile of human seminal plasma.

    Immunology today·2014
    Same author

    Treatment of Pellagra with Nicotinic Acid.

    British medical journal·2010
    Same author

    Respiratory allergy: Clinical aspects.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Magnetic support of the optical emission line filaments in NGC 1275.

    Nature·2008
    Same author

    How does auranofin compare with methotrexate and cyclosporin as a corticosteroid-sparing agent in severe asthma?

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
    Same journal

    Tamoxifen-driven neutrophil reprogramming protects from pulmonary Granulibacter bethesdensis infection in chronic granulomatous disease.

    The Journal of allergy and clinical immunology·2026
    Same journal

    Clinical and transcriptomic characterization of mixed granulocytic COPD phenotype.

    The Journal of allergy and clinical immunology·2026
    Same journal

    Dupilumab outcomes in pediatric asthma by early eosinophil status: post hoc analysis of VOYAGE/EXCURSION.

    The Journal of allergy and clinical immunology·2026
    Same journal

    Maternal antibiotic exposure alters the newborn metabolomic profile and increases the risk of respiratory infections in offspring: a 13-year longitudinal birth cohort study.

    The Journal of allergy and clinical immunology·2026
    Same journal

    Selective Elimination of Mast Cells via Siglec-6-Targeted Nanodelivery of Drug Payload.

    The Journal of allergy and clinical immunology·2026
    Same journal

    Loss of epidermal miR-149 sensitizes to skin inflammation.

    The Journal of allergy and clinical immunology·2026
    See all related articles

    Patients with nasal allergy exhibit reduced platelet aggregation during allergy season, particularly with epinephrine and collagen. This dysfunction, linked to a serum factor, suggests allergy as a model for studying platelet dysfunction.

    Area of Science:

    • Immunology
    • Hematology
    • Allergology

    Background:

    • Nasal allergy is a common condition affecting many individuals seasonally.
    • Platelet function is crucial for hemostasis and can be influenced by various physiological states.

    Purpose of the Study:

    • To investigate platelet aggregation responses in patients with seasonal nasal allergy.
    • To identify potential factors contributing to platelet dysfunction during the allergy season.

    Main Methods:

    • Studied platelet aggregation in 32 patients with nasal allergy during peak season.
    • Repeated tests out-of-season and analyzed responses to epinephrine, collagen, adenosine diphosphate (ADP), and thrombin.
    • Investigated the effect of an in-season serum factor on platelet aggregation.

    Related Experiment Videos

    Main Results:

    • 25 of 32 patients showed diminished platelet aggregation during allergy season.
    • Responses to epinephrine and collagen improved out-of-season; ADP and thrombin responses remained unchanged.
    • An in-season serum factor significantly inhibited platelet aggregation in normal platelets.

    Conclusions:

    • Seasonal nasal allergy is associated with reversible platelet dysfunction.
    • A serum factor present during the allergy season appears to cause platelet dysfunction.
    • Allergic diathesis serves as a model for studying non-drug-induced, cyclic platelet dysfunction.