[Are des-Phe-insulin-containing insulin combinations preferable to regular trade preparations?]

Des-phe-insulins are modified insulins in which phenylalanin is eliminated from the b-chain of the normal insulin. Preparations containing des-phe-insulin and cristalline insulin have a good stability and one can produce insulins with different profiles. 50 diabetics were treated with different des-phe-insulin containing preparations. The carbohydrate metabolism was well controlled during the application of the new preparations. There were no side effects nor skin allergies. Des-phe-insulin containing insulins present a new interesting aspect in the treatment of insulin dependent diabetes mellitus.