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Age-related decrease in cardiac and peripheral vascular responsiveness to isoprenaline: studies in normal subjects

P van Brummelen, F R Bühler, W Kiowski

    Clinical Science (London, England : 1979)
    |May 1, 1981
    PubMed
    Summary
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    Older adults show reduced beta-adrenoceptor responses in the heart, blood vessels, and kidneys compared to younger individuals. This age-related decline impacts cardiovascular and renal functions.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology
    • Gerontology

    Background:

    • Beta-adrenoceptor function is crucial for regulating heart rate, blood flow, and renin release.
    • Age-related changes in adrenergic receptor sensitivity are not fully understood.
    • Previous studies suggest potential declines in beta-adrenergic responsiveness with aging.

    Purpose of the Study:

    • To investigate age-related differences in beta-adrenoceptor-mediated responses.
    • To compare forearm blood flow and cardiac responses to isoprenaline in young and older adults.
    • To assess the relationship between catecholamines, renin activity, and vascular responses in different age groups.

    Main Methods:

    • 15 healthy volunteers (8 young, <25 yrs; 7 old, >50 yrs) participated.

    Related Experiment Videos

  • Forearm blood flow measured during intra-arterial isoprenaline infusion.
  • Cardiac chronotropic response to intravenous isoprenaline assessed.
  • Blood pressure, plasma renin activity, adrenaline, and noradrenaline levels measured.

    • Main Results:

    • Younger subjects showed significantly greater forearm blood flow increase and cardiac isoprenaline responsiveness (heart rate increase, P < 0.001).
    • Higher plasma renin activity observed in young subjects (P < 0.02).
    • Noradrenaline correlated with forearm blood flow and vascular resistance in older adults, while adrenaline correlated in younger adults.

    Conclusions:

    • Data indicate an age-related parallel reduction in cardiac, peripheral vascular, and renal beta-adrenoceptor-mediated responses.
    • These findings highlight significant functional declines in adrenergic signaling with advancing age.
    • Age impacts multiple organ systems' responsiveness to beta-adrenergic stimulation.