[Combined action of UV light and alpha particles on yeast cells of different genotypes]

Combined action of ultraviolet (UV) light and alpha-particles on yeast cells of different genotypes has been studied. Under combined action, after small doses of UV-light the oscillated changes of cell survival were registered for wild-type cells independent of the ploidy and the sequence of application of radiations. Additive effect of high doses of UV-light and ionizing radiation was expressed for strains incapable of the recovery of damages induced by ionizing radiation. For yeast cells possessing such a capability, the synergistic interaction of damages inflicted by high doses of UV-light and alpha-particles was noted. Possible reasons of the observed cell responses are discussed.