Brain-reactive antibodies in sera of aging non-human primates

Previous studies in our laboratory demonstrated an age-related increase in the brain-reactive antibodies in sera of aging mice. The present paper deals with the study of brain-reactive antibodies in sera of non-human primates (Macaca nemestrina) of three age groups (4, 10 and 20 years) by an indirect immunofluorescence method. The results indicated a progressive increase in the serum levels of these antibodies with advancing age. Since all three age groups examined demonstrated brain-reactive antibodies in sera, the age of onset of these antibodies could not be determined in these animals. It has been suggested that the formation of these antibodies could be evidence of autoimmune reactions which might play a significant role in neuronal degeneration during aging.