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Related Experiment Videos

Right ventricular performance in essential hypertension after beta-blockade

J Ferlinz, J L Easthope, D Hughes

    British Heart Journal
    |July 1, 1981
    PubMed
    Summary

    Beta-blockers like oxprenolol and propranolol can impair right ventricular function in hypertensive patients. This effect, previously thought to be limited to the left heart, requires caution when initiating treatment.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Systemic hypertension is known to impair right ventricular performance.
    • Beta-blockade is a common treatment for hypertension, raising concerns about its effects on right ventricular contractility.

    Purpose of the Study:

    • To evaluate the impact of different beta-adrenoceptor blocking agents on right ventricular myocardial contractility in patients with essential hypertension.
    • To determine if oxprenolol and propranolol differentially affect right ventricular function.

    Main Methods:

    • A double-blind, randomized study involving 20 patients with essential hypertension.
    • Patients received oral oxprenolol or propranolol for five weeks.
    • Cardiac catheterization and right ventricular cineangiography were performed before and after treatment.

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    Main Results:

    • Chronic beta-blockade led to a significant decrease in right ventricular ejection fraction and an increase in right ventricular end-systolic volume index.
    • Cardiac index decreased in both groups, though not significantly.
    • No statistically significant differences were observed between oxprenolol and propranolol in their effects on measured indices.

    Conclusions:

    • Both oxprenolol and propranolol impair right ventricular performance in hypertensive patients.
    • This impairment of right ventricular contractility by beta-blockade is a significant finding, previously thought to be limited to the left side of the heart.
    • Caution is advised when initiating beta-blockade in hypertensive patients with pre-existing right ventricular dysfunction to prevent decompensation.