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Quantitative methods in assessment of neurologic function

A R Potvin, W W Tourtellotte, K Syndulko

    Critical Reviews in Bioengineering
    |January 1, 1981
    PubMed
    Summary
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    Quantitative tests enhance neurologic function assessment in clinical trials. Careful selection and evaluation of sensory and motor function tests are crucial for objective clinical trial evaluation.

    Area of Science:

    • Neurology
    • Psychology
    • Clinical Trials

    Background:

    • Traditionally, neurologists relied on qualitative methods for clinical trial assessment.
    • Quantitative tests, common in psychology, are increasingly augmenting qualitative evaluations in neurology.
    • The validity of quantitative methods in a clinical setting requires direct assessment.

    Purpose of the Study:

    • To review and assess literature on asymptomatic human performance and quantitative neurologic function in clinical settings.
    • To identify and evaluate quantitative tests suitable for clinical neurologic trials.
    • To interpret the impact of various factors on test performance and reliability.

    Main Methods:

    • Literature review of asymptomatic human performance and clinical quantitative neurologic function.

    Related Experiment Videos

  • Assessment of tests for reproducibility, reliability, and validity.
  • Evaluation of examiner training, motivation, learning, handedness, age, and sex effects.

    • Main Results:

    • Quantitative tests measure various neurologic functions including mental state, strength, coordination, and simulated daily living activities.
    • Statistical strategies for data analysis, scoring, data reduction, and display are presented.
    • Carefully selected and evaluated sensory and motor function tests are essential for objective clinical trial evaluation.

    Conclusions:

    • Quantitative tests offer objective measures for neurologic functions in clinical trials.
    • Further research is needed, but validated quantitative sensory and motor tests are vital for objective clinical trial outcomes.
    • The integration of quantitative methods promises more rigorous neurologic clinical trial evaluations.