A safety trial with rafoxanide in sheep

Six groups of 6 lambs each were treated orally with rafoxanide at dosages ranging from 0 to 37,5 mg/kg live mass in multiples of 7,5 mg/kg. The lambs were slaughtered 27 to 31 d after treatment for post mortem examination. No clinical, ophthalmological or pathological changes attributable to treatment were detected in any of the lambs. Possible differential diagnoses and predisposing factors for rafoxanide toxicity are discussed. It is suggested that plasma-rafoxanide assay be used as a diagnostic tool.