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Lymphocytes bearing single or double surface immunoglobulins in umbilical cord blood

M C García Rodríguez, G Fontán, F Lorente

    Allergologia Et Immunopathologia
    |March 1, 1981
    PubMed

    Lymphocytes from the umbilical cord blood of 20 newborn infants and the peripheral blood of 18 adult volunteers, were studied for surface-stable immunoglobulins by the direct immunofluorescence technique. Goat antiserums to human light and heavy chains were used. Cord blood yielded a significantly higher percentage of lymphocyte bearing mu + delta chains, and a lower percentage bearing only delta chains. The number of B cells bearing light chains (K + lambda) or heavy chains (mu + delta +(mu + delta) was higher in cord blood than in the adult peripheral blood. The high percentage of cells bearing double markers (probably virgin B-cells) and the low number of cells bearing only IgD, (probably the cells responsible for secondary antibody responses) could be explained by the inhibition of the IgM-to-IgG switch in the antibody production of newborns.

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