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Related Experiment Videos

Is acquired immunological tolerance genetically transmissible?

E Nisbet-Brown, T G Wegmann

    Proceedings of the National Academy of Sciences of the United States of America
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    This study investigated if acquired immune tolerance could be inherited through male mice. Researchers found no evidence that this specific immunological tolerance was passed down to offspring.

    Area of Science:

    • Immunology
    • Genetics
    • Transplantation

    Background:

    • Acquired characteristics, traits developed during an organism's lifetime, are generally not considered heritable.
    • The transmission of acquired traits through germ cells remains a complex and debated topic in biology.
    • Immunological tolerance, a state of unresponsiveness to specific antigens, can be acquired.

    Purpose of the Study:

    • To investigate the potential vertical transmission of acquired immunological tolerance from male mice to their offspring.
    • To determine if specific tolerance to major histocompatibility antigens can be inherited through the male germ line.
    • To assess the heritability of acquired immune tolerance using established in vivo models.

    Main Methods:

    • Utilized tetraparental mice and separated parabionts exhibiting stable lymphoid chimerism as models for tolerant males.

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  • Assessed tolerance in progeny through two in vivo assays: cardiac allograft rejection and clearance of radio-iodinated tumor cells.
  • Compared immune responses in offspring of tolerant males versus control groups.

    • Main Results:

    • No evidence of heritability for the acquired tolerant state was observed in the progeny of either tetraparental or parabiont males.
    • Both cardiac allograft rejection and tumor cell clearance assays failed to demonstrate transmission of tolerance.
    • The study did not find support for the inheritance of acquired immunological tolerance in this model system.

    Conclusions:

    • The findings suggest that acquired immunological tolerance to major histocompatibility antigens is not transmitted through the male germ line in the studied mouse models.
    • This research contributes to the understanding of the boundaries between acquired traits and heritable genetic information.
    • Further research may be needed to explore alternative mechanisms or different types of acquired characteristics.