[Specific binding of 125I-insulin by fat cell plasma membranes in acromegaly]

Insulin receptors from fatty cell cytoplasmatic membranes were studied in 8 patients with acromegalia, who did not exhibit distinct impairments in carbohydrate metabolism. Concentration of insulin receptors was decreased 1.5-fold in the patients as compared with healthy people. However, affinity of free and blocked receptors to insulin as well as the degree of negative cooperativity between them were not distinctly altered.