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Histopathology of marine vibrio wound infections
Abstract:
Although marine vibrio wound infections and septicemia are being reported with increasing frequency, description of the histopathologic changes has been scanty. The histologic alterations in three patients with primary marine vibrio wound infections are presented. The lesions are characterized by intense acute cellulitis of the subcutis with much tissue destruction and extension into the adjacent dermis. The superficial dermis is devitalized and lacks an inflammatory cellular infiltrate. Subepidermal noninflammatory bullae are formed. Many organisms are seen both within the areas of intense acute inflammation and in devitalized areas. Organisms and inflammation are especially oriented around vessels, with associated acute vasculitis. It is concluded that the morphologic picture in marine vibrio wound infections is nonspecific yet characteristic.
Insights
Marine Vibrio bacteria cause severe wound infections and septicemia. Histopathology reveals intense tissue destruction, vasculitis, and characteristic but nonspecific lesions in affected patients.
Area of Science:
- Medical Microbiology
- Pathology
Background:
- Marine Vibrio wound infections and septicemia are increasing.
- Histopathologic descriptions of these infections are limited.
Observation:
- Three cases of primary marine Vibrio wound infections were analyzed.
- Lesions showed acute cellulitis, significant tissue destruction, and dermal necrosis.
Findings:
- Devitalized superficial dermis lacked inflammatory cells.
- Subepidermal bullae formed without inflammation.
- Organisms were found in inflamed and necrotic areas, often around vessels with vasculitis.
Implications:
- The histopathologic findings are nonspecific but characteristic of marine Vibrio infections.
- Understanding these changes aids in diagnosing and managing severe Vibrio wound cases.