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Related Experiment Videos

Barrier function of epithelia

D W Powell

    The American Journal of Physiology
    |October 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Epithelial barrier function, crucial for preventing harmful agent permeation, is reviewed. Active sodium (Na+) transport may play a key role in maintaining this barrier, impacting gastrointestinal health.

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    Area of Science:

    • Physiology
    • Cell Biology
    • Biophysics

    Background:

    • Epithelial barrier function, the ability to prevent noxious agent permeation, is critical but understudied beyond the gastrointestinal tract.
    • Hydrogen ion (H+) exclusion in the gastrointestinal tract highlights the clinical significance of epithelial barrier properties.
    • Understanding epithelial transport physiology is essential for comprehending barrier function.

    Purpose of the Study:

    • To review permeation routes across epithelia, integrating electrophysiological and morphological findings.
    • To examine the influence of various physical and chemical agents on epithelial permeability and permselectivity.
    • To place gastrointestinal barrier function concepts within the broader framework of transport physiology.

    Main Methods:

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  • Review of extensive electrophysiological studies on epithelial transport.
  • Analysis of morphological studies demonstrating permeation routes.
  • Consideration of data on the effects of physical agents, cations, organic compounds, nucleotides, and H+.

    • Main Results:

    • Epithelial barrier function involves both permeability and permselectivity.
    • Physical agents, polyvalent cations, organic compounds, cyclic nucleotides, and H+ affect barrier and transport functions.
    • Active sodium (Na+) transport is postulated to be important for maintaining epithelial barrier integrity.

    Conclusions:

    • Epithelial barrier function is a complex interplay of permeability and permselectivity.
    • Numerous factors, including H+, significantly influence epithelial barrier properties.
    • Active Na+ transport emerges as a potentially crucial mechanism for sustaining epithelial barrier function.