Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathologic changes induced by an euthanasia agent

C D Port, P J Garvin, C E Ganote

    Laboratory Animal Science
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rectal cancer following a kidney-pancreas transplant.

    Transplantation proceedings·2002
    Same author

    Combined cardio-renal transplantation (CCRT) from the same donor: report of two cases and review of the literature.

    Annals of the Royal College of Surgeons of England·2002
    Same author

    Cavoportal hemitransposition in liver transplantation.

    Transplantation·2001
    Same author

    Ischemic loss of sarcolemmal dystrophin and spectrin: correlation with myocardial injury.

    Journal of molecular and cellular cardiology·2001
    Same author

    Small bowel perforation from a migrated biliary stent.

    Surgical endoscopy·2001
    Same author

    Assessing depression in systemic lupus erythematosus: determining reliable change.

    Lupus·2001
    Same journal

    Major histocompatibility haplotype does not impact the course of experimentally induced murine vaginal candidiasis.

    Laboratory animal science·2000
    Same journal

    Pathologic changes associated with use of tribromoethanol (avertin) in the Sprague Dawley rat.

    Laboratory animal science·2000
    Same journal

    Depressive effects of anesthesia or sedation on exocrine pancreatic function in pigs.

    Laboratory animal science·2000
    Same journal

    Effects of histamine, carbachol, and methacholine on maximal expiratory lung mechanics in goats.

    Laboratory animal science·2000
    Same journal

    Comparison of three treatments for control of ear mites in ferrets.

    Laboratory animal science·2000
    Same journal

    Comparison of two systems for tibial external fixation in rabbits.

    Laboratory animal science·2000
    See all related articles

    High doses of T-61 euthanasia solution in dogs and cats can cause lung and kidney lesions. These pathological changes, observed 15 minutes post-injection, are considered euthanasia artifacts, impacting animal research integrity.

    Area of Science:

    • Veterinary Pathology
    • Animal Euthanasia Studies

    Background:

    • Euthanasia methods in veterinary medicine require careful validation.
    • Pathological changes post-euthanasia can complicate research findings.

    Purpose of the Study:

    • To investigate the potential for gross and microscopic pathological changes following T-61 or pentobarbital euthanasia in dogs and cats.
    • To determine if observed lesions are true pathological findings or artifacts of the euthanasia procedure.

    Main Methods:

    • Dogs and cats were euthanized using intravenous T-61 (0.3 ml/kg or 1.0–1.5 ml/kg) or pentobarbital (100 mg/kg).
    • Animals were necropsied at <5 minutes or 15 minutes post-injection.
    • Gross and microscopic pathological examinations of tissues were performed.

    Related Experiment Videos

    Main Results:

    • No significant pathological changes were observed in animals euthanized with low-dose T-61 or pentobarbital.
    • High-dose T-61 (1.0–1.5 ml/kg) resulted in severe pulmonary edema, lung congestion, and endothelial necrosis in lungs and kidneys.
    • These lesions were observed at 15 minutes post-injection and classified as euthanasia artifacts.

    Conclusions:

    • High doses of T-61 can induce significant pulmonary and renal lesions in dogs and cats.
    • These lesions are considered artifacts of the euthanasia process, not indicative of pre-existing pathology.
    • Careful consideration of euthanasia agent dosage and timing is crucial to avoid confounding research results.