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Enzyme electrodes as practical biosensors

P Vadgama

    Journal of Medical Engineering & Technology
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Enzyme electrodes combine enzymes with electrochemical sensors for biochemical assays. This review highlights their potential for medical measurements and continuous in vivo monitoring, despite current underutilization.

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    Area of Science:

    • Biomedical Engineering
    • Electrochemistry
    • Biochemistry

    Background:

    • Enzyme electrodes integrate enzymes with electrochemical sensors to quantify specific substrates.
    • These biosensors have facilitated the analysis of numerous biochemically relevant compounds.
    • Despite their utility, enzyme electrodes are currently underutilized in clinical diagnostics.

    Purpose of the Study:

    • To review the fundamental principles of enzyme electrode technology.
    • To describe enzyme electrodes suitable for biological solutions and associated challenges.
    • To emphasize the potential of enzyme electrodes for continuous in vivo monitoring.

    Main Methods:

    • Literature review of enzyme electrode principles and applications.
    • Discussion of electrode designs for biological environments.

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  • Analysis of challenges and future directions for in vivo monitoring.

    • Main Results:

    • Enzyme electrodes offer a method for substrate measurement via enzymatic reactions.
    • Various enzyme electrodes have been developed for biochemical assays.
    • Significant challenges exist in their application to medical measurements and in vivo use.

    Conclusions:

    • Enzyme electrodes possess considerable, yet largely untapped, potential in medical diagnostics.
    • Further development is needed to overcome challenges for widespread clinical adoption.
    • Continuous in vivo monitoring represents a key area for future enzyme electrode advancement.