Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation in nonsystemic glomerular diseases in children

M Levy, R Habib

    Paediatrician
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Modification of the renal response to endopeptidase inhibition and atrial natriuretic peptide infusion in normal dogs.

    Canadian journal of physiology and pharmacology·1992
    Same author

    Uncontrolled asthma.

    The Practitioner·1992
    Same author

    Paracetamol overdose in Jerusalem, 1984-89.

    Israel journal of medical sciences·1992
    Same author

    Renal tubular responsiveness to atrial natriuretic peptide in sodium-retaining chronic caval dogs. A possible role for kinins and luminal actions of the peptide.

    The Journal of clinical investigation·1992
    Same author

    Portal venous infusions of L-glutamine in anaesthetized dogs do not influence renal function.

    Canadian journal of physiology and pharmacology·1992
    Same author

    Prediction of Helicobacter pylori in gastric specimens by inflammatory and morphological histological evaluation.

    The American journal of gastroenterology·1992
    Same journal

    Improving the nutrition of the child. With particular reference to developing countries.

    Paediatrician·1982
    Same journal

    Promoting psychosocial functioning and preventing malfunctioning.

    Paediatrician·1982
    Same journal

    BOEL-a screening program to enlarge the concept of infant health.

    Paediatrician·1982
    Same journal

    Prevention of mental retardation.

    Paediatrician·1982
    Same journal

    Prenatal care and child health.

    Paediatrician·1982
    Same journal

    Factors related to perinatal morbidity and mortality. Risk factors in pregnancy influencing perinatal morbidity and mortality.

    Paediatrician·1982
    See all related articles

    The complement system, crucial in immune-mediated glomerulonephritis (GN), aids in identifying kidney injury pathways. Understanding complement activation is key to diagnosing and treating pediatric glomerular diseases.

    Area of Science:

    • Immunology
    • Nephrology
    • Molecular Biology

    Background:

    • Glomerulonephritis (GN) pathogenesis is largely immunological.
    • The complement system is a key mediator of renal injury in GN.
    • Identifying complement's role aids in diagnosing glomerular diseases.

    Purpose of the Study:

    • To review complement activation mechanisms and detection methods.
    • To summarize current knowledge of complement's role in pediatric nonsystemic glomerular diseases.

    Main Methods:

    • Review of molecular events in complement activation.
    • Description of methods for studying the human complement system.
    • Classification of GN based on microscopy (light, electron, immunofluorescence).

    Related Experiment Videos

    Main Results:

    • Complement system activation is central to immunologically mediated GN.
    • Specific GN types discussed include endocapillary-proliferative GN with humps, extramembranous GN, membranoproliferative GN, and mesangial IgA GN.
    • Complement studies are vital for understanding these conditions.

    Conclusions:

    • Complement system activation is a common pathway in various glomerulonephritis forms.
    • Understanding complement is essential for diagnosing and managing pediatric glomerular diseases.
    • Morphological classification aids in identifying specific GN types and their underlying mechanisms.