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Prostacyclin is not a circulating hormone

E Christ-Hazelhof, D H Nugteren

    Prostaglandins
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Prostacyclin (PGI2) was undetectable in normal human blood, even during hyperventilation. Elevated levels were only found during PGI2 infusion or in shock, challenging its role as a normal circulating hormone.

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    Area of Science:

    • Biochemistry
    • Physiology
    • Pharmacology

    Background:

    • Prostacyclin (PGI2) is a potent vasodilator and inhibitor of platelet aggregation.
    • Its role as a circulating hormone under normal physiological conditions remains debated.
    • Previous studies have yielded conflicting results regarding PGI2 levels in blood.

    Purpose of the Study:

    • To accurately quantify prostacyclin (PGI2) levels in human blood under various conditions.
    • To investigate the potential of PGI2 as a circulating hormone.
    • To determine PGI2 levels during physiological stress and pathological states.

    Main Methods:

    • Gas chromatography with electron-capture detection was employed.
    • Pentafluorobenzyl derivatives of 6-oxo-PGF1 alpha were analyzed.

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  • Blood samples were collected from peripheral circulation, heart chambers, and during PGI2 infusion.

    • Main Results:

    • Prostacyclin (PGI2) was not detectable (<20 pg/ml) in peripheral or central human blood under normal conditions.
    • No detectable PGI2 formation was observed even during hyperventilation.
    • Significant PGI2 levels were detected during intravenous infusion and in cases of severe infection and endotoxin shock.

    Conclusions:

    • Prostacyclin (PGI2) does not appear to function as a circulating hormone in healthy individuals.
    • Elevated PGI2 levels are associated with exogenous administration and critical conditions like shock and infection.
    • The findings challenge the concept of PGI2 as a continuously circulating hormone.