Related Experiment Videos
Midazolam, a new intravenous induction agent for anaesthesia
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|February 20, 1982
Summary
Midazolam, a new anesthetic, offers rapid induction and recovery with good patient acceptance and local tolerance. This study suggests it is a viable option for balanced anesthesia induction.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Balanced anesthesia requires effective induction agents.
- Midazolam is a benzodiazepine with potential anesthetic properties.
Purpose of the Study:
- To evaluate midazolam (Ro 21-3981) as an intravenous agent for induction of balanced anesthesia.
- To assess patient recovery, amnesia, and local tolerance.
Main Methods:
- An open, non-comparative trial involving 64 adult patients (ASA I-II).
- Anesthesia induced with midazolam (0.15 or 0.3 mg/kg IV), followed by endotracheal intubation and maintenance with nitrous oxide/oxygen and enflurane/halothane.
Main Results:
- Statistically significant cardiovascular changes occurred post-intubation but without clinical impact.
- Patients experienced rapid induction and recovery from anesthesia.
- No retrograde amnesia was observed; most patients found induction favorable.
- Excellent local tolerance to midazolam was reported.
Conclusions:
- Midazolam facilitates rapid induction and recovery from anesthesia.
- It is well-tolerated locally and does not cause retrograde amnesia.
- Midazolam presents a promising alternative for inducing balanced anesthesia.