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Chromium (III) metabolism by the kidney
Annals of Clinical and Laboratory Science
|September 1, 1981
Summary
The kidney excretes chromium, but its reabsorption varies. Chromium (III)-EDTA chelate aids in measuring kidney filtration, with potential implications for diabetes mellitus research.
Area of Science:
- Nephrology
- Trace Element Metabolism
- Biochemistry
Background:
- The kidney is the primary organ for excreting the essential trace element chromium.
- Previous research indicates significant reabsorption of filtered chromium (III) in renal tubules, with a portion being ultrafilterable.
- A stable chromium (III)-EDTA chelate shows minimal reabsorption, making it a tool for glomerular filtration rate assessment.
Purpose of the Study:
- To explore the renal handling of chromium and its implications in physiological states.
- To investigate the utility of chromium complexes in assessing kidney function.
- To understand factors influencing chromium excretion, such as glucose challenges and diuresis.
Main Methods:
- Review of existing literature on chromium excretion and reabsorption in the kidney.
- Analysis of studies utilizing chromium (III)-EDTA chelate for glomerular filtration measurement.
- Discussion of postulated mechanisms for increased chromium excretion in conditions like diabetes mellitus.
Main Results:
- Significant variability in chromium (III) ultrafiltration and reabsorption percentages reported.
- Chromium (III)-EDTA chelate demonstrates low reabsorption, supporting its use in glomerular filtration rate estimation.
- Glucose challenges or volume diuresis may increase fractional excretion of chromium.
Conclusions:
- Chromium excretion and metabolism studies require careful interpretation due to analytical challenges and the potential non-equivalence of chromium salts.
- Refined analytical techniques are crucial for understanding chromium homeostasis and identifying metabolic abnormalities.
- Further research is needed to fully elucidate the role of chromium in kidney function and disease.
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