Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between circulating immune complexes and urinary antigens in human malignancy

J F Huth, R K Gupta, D L Morton

    Cancer
    |March 15, 1982
    PubMed
    Summary

    Tumor-associated antigens (UA) and circulating immune complexes (CIC) were measured in melanoma and sarcoma patients. Findings suggest kidney damage from immune complexes may lead to antigen excretion in urine.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The use of sentinel lymphadenectomy to identify candidates for postoperative adjuvant therapy of melanoma and breast cancer.

    Seminars in oncology·2001
    Same author

    Cytoreductive surgery and adjuvant immunotherapy: a new management paradigm for metastatic melanoma.

    CA: a cancer journal for clinicians·2001
    Same author

    Immunology of gangliosides.

    Indian journal of experimental biology·2001
    Same author

    Molecular staging of early colon cancer on the basis of sentinel node analysis: a multicenter phase II trial.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2001
    Same author

    Tumor-associated antigen TA90 immune complex assay predicts recurrence and survival after surgical treatment of stage I-III melanoma.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2001
    Same author

    The clinical utility of multimarker RT-PCR in the detection of occult metastasis in patients with melanoma.

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2000

    Area of Science:

    • Oncology
    • Immunology
    • Nephrology

    Background:

    • Tumor-associated antigens (UA) are potential biomarkers for cancer detection.
    • Circulating immune complexes (CIC) are implicated in various autoimmune and malignant diseases.
    • The presence and significance of UA and CIC in urine and serum of cancer patients require further investigation.

    Purpose of the Study:

    • To analyze the presence of UA in urine and CIC in serum of patients with melanoma and sarcoma.
    • To investigate the correlation between urinary UA and serum CIC levels in these cancer patients.
    • To explore the potential role of kidney damage in the excretion of tumor antigens.

    Main Methods:

    • Urine samples were analyzed for UA using complement fixation and enzyme immunoassay.

    Related Experiment Videos

  • Serum samples were analyzed for CIC using complement consumption and K562 radiometric assay.
  • Correlation analysis was performed between UA and CIC detection in cancer patients.

    • Main Results:

    • A significant correlation was observed between the presence of urinary UA and serum CIC in cancer patients.
    • 78% of patients positive for UA were also positive for CIC, and 50% of patients negative for CIC were negative for UA.
    • Parallel fluctuations of CIC and UA were noted in a melanoma patient during treatment, suggesting a dynamic relationship.

    Conclusions:

    • Excretion of tumor-associated antigens into urine is linked to the presence of circulating immune complexes.
    • Immune complex deposition in the kidneys may cause glomerular damage, facilitating antigen passage into urine.
    • These findings highlight a potential mechanism for tumor antigenuria and its association with systemic immune responses in cancer.