Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemotherapy-induced immunosuppression

L Rasmussen, A Arvin

    Environmental Health Perspectives
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Chemotherapy and immunosuppressive drugs weaken the immune system, increasing infection risks. Monitoring immune function is crucial for patients undergoing such treatments to manage these vulnerabilities.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Systematic transcriptomic analysis and temporal modelling of human fibroblast senescence.

    Frontiers in aging·2024
    Same author

    Psychotropic drug use among children and adolescents in the Nordic countries: a systematic review.

    European child & adolescent psychiatry·2024
    Same author

    Intraoperative ultrasound imaging in the surgical treatment of congenital hyperinsulinism: prospective, blinded study.

    BJS open·2021
    Same author

    Does software optimization influence the radiologists' perception in low dose paediatric pelvic examinations?

    Radiography (London, England : 1995)·2019
    Same author

    Postoperative complications following percutaneous endoscopic gastrostomy are common in children.

    Acta paediatrica (Oslo, Norway : 1992)·2017
    Same author

    Scrotal testis size in unilateral non-palpable cryptorchidism, what it can and cannot tell: Study of a Middle Eastern population.

    Journal of pediatric urology·2017
    Same journal

    A New Start.

    Environmental health perspectives·2026
    Same journal

    Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

    Environmental health perspectives·2026
    Same journal

    Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

    Environmental health perspectives·2026
    Same journal

    Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

    Environmental health perspectives·2026
    Same journal

    Workflow for Statistical Analysis of Environmental Mixtures.

    Environmental health perspectives·2026
    Same journal

    Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

    Environmental health perspectives·2026
    See all related articles

    Area of Science:

    • Immunology
    • Pharmacology
    • Oncology

    Background:

    • Immunosuppression is a key therapeutic strategy in managing various diseases, including autoimmune disorders, lymphoproliferative diseases, and organ transplant rejection.
    • Commonly used immunosuppressive agents include ionizing irradiation, corticosteroids, alkylating agents, antilymphocyte sera, and antimetabolites.
    • While the molecular mechanisms of these agents are understood, their precise impact on cellular immune events remains less clear.

    Purpose of the Study:

    • To review the categories and applications of immunosuppressive agents in clinical medicine.
    • To highlight the importance of understanding the effects of immunosuppression on immune responses.
    • To discuss the increased susceptibility to opportunistic infections and malignancies following immunosuppressive therapy.

    Related Experiment Videos

    Main Methods:

    • Review of established immunosuppressive agents and their clinical indications.
    • Discussion of the known molecular actions and less understood cellular effects of these agents.
    • Description of methods for monitoring humoral and cellular immunity parameters.

    Main Results:

    • Chemotherapeutic agents are widely used to reduce host immune response for specific medical conditions.
    • Immunosuppression can lead to increased susceptibility to opportunistic pathogens and malignancies.
    • Studies reveal specific defects in cell-mediated immunity, particularly against herpes viruses, in patients treated with immunosuppressive drugs.

    Conclusions:

    • Effective monitoring of immune function is essential in patients receiving immunosuppressive therapy.
    • Understanding the impact of immunosuppression on cellular immunity is critical for managing patient risk.
    • Defects in cell-mediated immunity may explain the increased susceptibility to certain infections in treated patients.