Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanical cardiopulmonary interdependence

T C Lloyd

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Positive end-expiratory pressure (PEEP) significantly impacts ventricular filling by increasing the elastic load on the heart. Lung and chest wall deformation contribute substantially to this load, affecting cardiopulmonary interdependence.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+.

    Cellular and molecular biology (Noisy-le-Grand, France)·1999
    Same author

    Influence of age on the inotropic response to acute ethanol exposure in spontaneously hypertensive rats.

    Hypertension (Dallas, Tex. : 1979)·1996
    Same author

    Acute and chronic effects of ethanol on papillary muscles from spontaneously hypertensive rats.

    European journal of pharmacology·1996
    Same author

    Effect of capillary pressure and lung distension on capillary recruitment.

    Journal of applied physiology (Bethesda, Md. : 1985)·1995
    Same author

    Effect of increasing flow on distribution of pulmonary capillary transit times.

    Journal of applied physiology (Bethesda, Md. : 1985)·1994
    Same author

    Computer simulation of neutrophil transit through the pulmonary capillary bed.

    Journal of applied physiology (Bethesda, Md. : 1985)·1993
    Same journal

    Metabolic control of cardiac output response to exercise in McArdle's disease.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Hypoxic insomnia: effects of carbon monoxide and acclimatization.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Quiet-breathing vs. panting methods for determination of specific airway conductance.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    A new method for raising neonatal rabbits in a hypoxic environment.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Modification of the cutaneous vascular response to exercise by local skin temperature.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    Same journal

    Temperature regulation during treadmill exercise in the rat.

    Journal of applied physiology: respiratory, environmental and exercise physiology·1984
    See all related articles

    Area of Science:

    • Cardiopulmonary Physiology
    • Respiratory Mechanics
    • Cardiac Function

    Background:

    • Cardiopulmonary interdependence describes the relationship between the respiratory and cardiovascular systems.
    • Positive end-expiratory pressure (PEEP) is a mechanical ventilation strategy that can influence cardiac function.
    • Understanding how PEEP affects ventricular filling is crucial for managing mechanically ventilated patients.

    Purpose of the Study:

    • To investigate cardiopulmonary interdependence during mechanical ventilation with PEEP.
    • To quantify the elastic load imposed on ventricular diastolic filling by PEEP.
    • To determine the contributions of lung and chest wall deformation to this load.

    Main Methods:

    • Studied ten pentobarbital sodium-anesthetized dogs.

    Related Experiment Videos

  • Measured left atrial pressure (Pla) changes to maintain constant cardiac output (Q) during PEEP.
  • Determined Pla reductions mimicking Q fall with PEEP.
  • Compared left ventricular pressure-volume curves with and without PEEP in freshly dead dogs.

    • Main Results:

    • Atrial pressure changes were partitioned into pleural pressure, lung deformation, and residual components.
    • Compliance opposing ventricular filling was 3.9 ml/cm H2O.
    • Compliance derived from pressure-volume curves was 6.8 ml/cm H2O, suggesting ventricular interdependence.
    • Respiratory system compliance opposing ventricular filling was significantly lower than predicted.

    Conclusions:

    • Lung and chest wall deformation represent a significant elastic load on ventricular diastolic filling during PEEP.
    • Cardiopulmonary interdependence significantly influences cardiac function under mechanical ventilation.
    • Ventricular interdependence may contribute to the observed differences in compliance measurements.