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Updated: Feb 13, 2026

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
Published on: June 29, 2021
A foreign body granuloma produced by an injectable collagen implant at a test site
Abstract:
Zyderm collagen implant, a solubilized, purified, bovine collagen preparation for augmentation of soft tissue, produced a foreign body granuloma in a 37-year-old woman who had no history of immunologic disorders or autoimmune disease. The patient had received a small test implant to determine if she were sensitive to Zyderm. A very slight, borderline response occurred and a second test implant was administered. This second implant resulted in a foreign body granuloma that has persisted for ten months.
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