Studies on the fibrinolytic effect of ocrase

The fibrino(geno)lytic activity of the non-specific proteolytic enzyme ocrase, a protease from Aspergillus ochraceus, was studied in rat plasma in vitro and in vivo. The proteolytic activity of ocrase was rapidly neutralized by plasmatic inhibitors. Ocrase concentrations which did not surpass the inhibitory capacity of rat plasma exerted predominantly fibrinolytic effects. Under these conditions, ocrase displayed a certain fibrin specificity causing thrombolysis.