Related Experiment Video

Updated: Sep 21, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin

G Murphy, T E Cawston, W A Galloway

    The Biochemical Journal
    |December 1, 1981
    PubMed

    More Related Videos

    Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates08:19

    Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

    Published on: April 22, 2019

    Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E09:48

    Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

    Published on: September 26, 2019

    Related Concept Videos

    Fibril-associated Collagen01:11

    Fibril-associated Collagen

    Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
    For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
    Role of Matrix Metalloproteases in Degradation of ECM01:23

    Role of Matrix Metalloproteases in Degradation of ECM

    Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
    A...
    Type IV Collagen of Basal Lamina01:05

    Type IV Collagen of Basal Lamina

    Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
    A type IV collagen molecule has six alpha chains which can exist in...
    Phases of Wound Repair01:28

    Phases of Wound Repair

    Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
    Formation of Blood Clot
    In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...