Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathologic patterns of Serratia marcescens pneumonia

J D Goldstein, J J Godleski, J P Balikian

    Human Pathology
    |May 1, 1982
    PubMed
    Summary

    Serratia marcescens pneumonia presents distinct lung lesions in non-neutropenic and immunosuppressed patients. Recognizing these patterns is crucial as nosocomial infections rise.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Leptospiral nephritis.

    Journal of the American Medical Association·2010
    Same author

    Acute pulmonary and hematological effects of two types of particle surrogates are influenced by their elemental composition.

    Environmental research·2004
    Same author

    Differential ability of transition metals to induce pulmonary inflammation.

    Toxicology and applied pharmacology·2001
    Same author

    Transmission electron microscopy of intracellular particles of polyethylene from joint replacement prostheses: size distribution and cellular response.

    Biomaterials·2001
    Same author

    A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation.

    The American journal of pathology·2001
    Same author

    Benign metastasizing leiomyoma: clinical, imaging, and pathologic correlation.

    AJR. American journal of roentgenology·2001

    Area of Science:

    • Pulmonary Pathology
    • Infectious Diseases
    • Microbiology

    Background:

    • Serratia marcescens is an opportunistic pathogen.
    • Nosocomial S. marcescens infections are increasing.
    • Pulmonary involvement can be severe.

    Purpose of the Study:

    • To characterize pulmonary lesions caused by Serratia marcescens.
    • To identify distinct histopathologic reactions in S. marcescens pneumonia.
    • To correlate histopathology with patient immune status.

    Main Methods:

    • Retrospective review of autopsy-culture-proven cases of S. marcescens pneumonia (1968-1980).
    • Analysis of histopathologic findings in lung tissue.
    • Identification of S. marcescens in pure cultures.

    Main Results:

    • Two distinct patterns of pulmonary lesions were observed.
    • Non-neutropenic patients: acute, hemorrhagic bronchopneumonia with microabscesses or cavities, and vasculitis.
    • Immunosuppressed patients: diffuse neutropenic pneumonitis resembling diffuse alveolar damage with hemorrhage and fibrinous exudates.

    Conclusions:

    • S. marcescens pneumonia exhibits recognizable histological patterns.
    • Histopathological findings differ between non-neutropenic and immunosuppressed patients.
    • Autopsy cultures positive for S. marcescens are diagnostically significant.

    Related Experiment Videos