Related Experiment Video

Updated: Aug 23, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

[The respiratory complications of D-Penicillamine therapy (author's transl)]

P Camus

    Revue Francaise Des Maladies Respiratoires
    |January 1, 1982
    PubMed

    Insights

    D-Penicillamine can cause serious lung problems like bronchiolitis obliterans and interstitial pneumonitis, especially in rheumatoid arthritis patients. Accurate reporting of these adverse pulmonary effects is crucial for understanding their frequency and impact.

    Area of Science:

    • Pulmonary Medicine
    • Rheumatology
    • Pharmacology

    Context:

    • D-Penicillamine is a chelating agent used to treat rheumatoid arthritis and other conditions.
    • Respiratory symptoms are a potential adverse effect of D-Penicillamine therapy.
    • Patients with rheumatoid arthritis are a primary population experiencing D-Penicillamine-induced pulmonary complications.

    Purpose:

    • To review the literature on D-Penicillamine-induced respiratory symptoms.
    • To detail the various pulmonary manifestations associated with D-Penicillamine.
    • To discuss diagnostic criteria, drug implications, and pathogenesis of these adverse effects.

    Summary:

    • The review covers bronchiolitis obliterans, interstitial pneumonitis, Goodpasture's-like syndrome, and bronchospasm as key respiratory complications.
    • Diagnostic criteria and pathogenesis for each condition are explored.
    • The review highlights the importance of accurate reporting of pulmonary adverse events to improve epidemiological data.

    Impact:

    • Provides clinicians with essential information for diagnosing and managing D-Penicillamine-induced lung diseases.
    • Emphasizes the need for vigilance and reporting of adverse pulmonary events.
    • Contributes to a better understanding of the drug's pulmonary toxicity and patient safety.

    More Related Videos

    Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung07:10

    Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

    Published on: May 20, 2019

    Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases03:22

    Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

    Published on: March 1, 2024

    Related Concept Videos

    Pneumonia III: Complications and Assessment01:30

    Pneumonia III: Complications and Assessment

    Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
    Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

    Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

    Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
    Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
    Primary Symptoms of COPD:
    Rheumatic Heart Disease I: Introduction01:23

    Rheumatic Heart Disease I: Introduction

    Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
    Rheumatic Heart Disease III: Medical Management01:21

    Rheumatic Heart Disease III: Medical Management

    Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
    Chronic Obstructive Pulmonary Disease II: Emphysema01:23

    Chronic Obstructive Pulmonary Disease II: Emphysema

    Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
    Pneumonia I: Introduction01:29

    Pneumonia I: Introduction

    Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...