Surface hydrophobicity of proteins and selectivity of intracellular proteolysis

The affinity of cytosol proteins from protein-free fed rats to hydrophobic surfaces is diminished in comparison to the affinity of cytosol proteins from normal or protein-rich fed rats. Furthermore, the affinity of these cytosol proteins to hydrophobic surfaces in the presence of ultrafiltrates from cytosol of rats fed previously a protein-rich diet or a protein-free diet is diminished. Ultrafiltration itself increases the affinity of cytosol proteins to hydrophobic surfaces (octyl-sepharose or phenyl-sepharose).