[Current status of the problem of the pathogenesis of sepsis]

The current concepts on the pathogenesis of sepsis are considered mainly from the point of view of host-microorganism interaction. The authors emphasize the conditionality of these concepts in terms of their considerable hypothetic nature and the lack of strictly scientific proofs. In their opinion, the problem may be solved by wider application of the currently available physiological, immunological, bacteriological, morphological, and other methods of investigation. It should be expected that the use of this complex of methods will first of all provide comprehensive information on the interaction of microorganisms with various physiological systems of the host in their exact qualitative and quantitative expressions.